Which genes contribute to variation in plasma cholesterol and triglyceride levels in the population?

Plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) are heritable risk factors for cardiovascular disease and targets for therapeutic intervention. The Kathiresan laboratory working with an international group of collaborators has led five genome-wide association studies for plasma lipids.  Results are summarized below. Study Total number … Read more

Are there any genes that protect people from risk for heart attack?

In one large family, we noticed that low levels of blood lipids (low LDL cholesterol, HDL cholesterol, and triglycerides) was present in several members of the family.  We described this syndrome as ˜familial combined hypolipidemia.  It looked as if a single gene was responsible for the low lipid levels in the family.  To discover the … Read more